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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Exp Cell Res. 2020 Nov 18;398(1):112386. doi: 10.1016/j.yexcr.2020.112386

Figure 4. C-bodies are associated with rDNA.

Figure 4.

(A–D) C-bodies often appear at the ends of the LBCs, at or near the 5S rDNA loci (arrows). About 16 of the 18 LBCs have one to a few pairs of C-bodies at their ends, consistent with the distribution of 5S ribosomal genes. (E–H) The cold shock treatment can induce nucleolar protrusions with a DAPI-positive structure at their root. HA-RPB6 reveals bright spots on the C-bodies (C) and at the root of the nucleolar protrusions (G). It should be noted that protrusions do not appear on every nucleolus.