Table 1.
Subject Characteristics (n=106)
| Variable | Total | IDH1-wild-type | IDH1-mutant | P-value |
|---|---|---|---|---|
| Number of patients, n (%) | 106 (100) | 83 (78.3) | 23 (21.7) | |
| Mean age, years (SD) | 37.6 (18.6) | 37.1 (20.1) | 39.3 (12.1) | 0.768# |
| Sex, n (%) | ||||
| Male | 58 (54.7) | 43 (51.8) | 15 (65.2) | 0.253 |
| Female | 48 (45.3) | 40 (48.2) | 8 (34.8) | |
| A history of smoking, n (%) | ||||
| Yes | 23 (29.9) | 15 (23.8) | 8 (57.1) | 0.022## |
| No | 54 (70.1) | 48 (76.2) | 6 (42.9) | |
| Karnofsky Performance Scale pre-surgery (n=85), mean ± SD | 53.2 (18.1) | 52.9 (18.3) | 54.7 (17.7) | 0.755# |
| Reported symptom of seizure, n (%) | ||||
| Yes | 25 (29.8) | 18 (26.5) | 7 (43.8) | 0.226## |
| No | 59 (70.2) | 50 (73.5) | 9 (56.2) | |
| Tumor location (include this lobe/not) | ||||
| Frontal | 26/52 | 17/45 | 9/7 | 0.029 |
| Temporal | 36/42 | 27/35 | 9/7 | 0.364 |
| Parietal | 32/46 | 25/37 | 7/9 | 0.804 |
| Occipital | 7/71 | 6/56 | 1/15 | 1## |
| Others | 16/62 | 15/47 | 1/15 | 0.169## |
| Histological type, n (%) | ||||
| astrocytic | 85 (80.2) | 71 (85.5) | 14 (62.5) | <0.001## |
| mixed (oligoastroglial) | 5 (4.7) | 2 (2.4) | 3 (12.5) | |
| oligodendroglial | 8 (7.55) | 2 (2.4) | 6 (25) | |
| ependymal | 8 (7.55) | 8 (9.6) | 0 (0) | |
| Grade, n (%) | ||||
| Grade I | 10 (9.4) | 9 (10.8) | 1 (4.4) | 0.091## |
| Grade II | 36 (34) | 23 (27.7) | 13 (56.5) | |
| Grade III | 17 (16) | 14 (16.9) | 3 (13) | |
| Grade IV | 43 (40.6) | 37 (44.6) | 6 (26.1) | |
| Combined grade, n (%) | ||||
| Grade I & IV | 54 (50.9) | 47 (56.6) | 7 (30.4) | 0.026 |
| Grade II & III | 52 (49.1) | 36 (43.4) | 16 (69.6) | |
| Ki67, mean (SD), n=93 | 13.4 (13.3) | 14.99 (13.97) | 7.7 (8.99) | 0.027# |
| MGMT promoter methylation, n (%) | ||||
| Methylated | 12 (25) | 7 (18) | 5 (55.6) | 0.032## |
| Unmethylated | 36 (75) | 32 (82) | 4 (44.4) | |
| Interval between onset of symptoms to initial surgical interventions, months (SD) (n=84) | 6.4 (10.1) | 4.64 (6.8) | 13.3 (16.6) | 0.025# |
| Median overall survival, month (SD) (n=80) | 23.8 (8.4) | 10.5 (3.3) | 42.4 (10.1) | 0.016### |
#, Mann-Whitney U test, ##, Fisher’s exact test, ###, Kaplan-Meier with log-rank test, Chi-square tests were performed for the rest of the analyses