Table 3.
The Frequency of Allele and Genotypes of rs4939827 Polymorphism of SMAD-7 Gene and Their Comparison in the Case and Control Groups
| SMAD-7 rs4939827 T>C | Case (breast cancer) N (%) | Control (healthy women) N (%) | OR (95%CI) | P-value |
|---|---|---|---|---|
| Codominant | ||||
| TT | 48 (23.4) | 71 (35.5) | 1 | - |
| CT | 121 (59.0) | 105 (52.5) | 1.71 (1.10-2.70) | 0.023 |
| CC | 36 (17.6) | 24 (12.0) | 2.22 (1.20-4.26) | 0.017 |
| Dominant | ||||
| TT | 48 (23.4) | 71 (35.5) | 1 | - |
| CT+CC | 157 (76.6) | 129 (64.5) | 1.80 (1.17-2.76) | 0.009 |
| Recessive | ||||
| CT+TT | 169 (82.4 | 176 (88.0) | 1 | - |
| CC | 36 (17.6) | 24 (12.0) | 1.56 (0.90-2.73) | 0.125 |
| Allele | ||||
| T | 217 (52.9) | 247 (62.7) | 1 | - |
| C | 193 (47.1) | 153 (38.3) | 1.44 (1.08-1.89) | 0.013 |