Figure 6.

Morphologic Changes Detected by SEM in MCF-7 Cell Line. a) MCF-7 control group possessed numerous microvilli and lamellipodia on the cell surface with intact cell membrane connection that facilitate adherence of the cells. b) hTERT siRNA transfected group showed a decreased number of microvilli with a striking collection of blebs (apoptotic bodies) on the cell surface and cell shrinkage. c) Cells treated with siRNA + Doxorubicin exhibited a decrease in the number of microvilli which became relatively smooth with no obvious microvilli and blebbing on the surface of cancer cells, meanwhile progressive cell shrinkage was detected. d) Cells treated with doxorubicin showed reduction in the number of microvilli