Table 2.
Associations of FGF23 with new-onset CKD
| Sex-specific tertiles of FGF23 (RU/mL), median (IQR) |
||||||
|---|---|---|---|---|---|---|
| ♂: <61.9 | ♂: 61.9–74.2 | ♂: >74.2 | ||||
| Model | ♀: <58.4 | ♀: 58.4–82.9 | ♀: >82.9 | |||
| New-onset CKD (n = 586) | Ptrend | Log2FGF23 (continuous), median (IQR) | P-value | |||
| 1 | 1.0 (Ref) | 1.11 (0.90–1.38) | 1.73 (1.42–2.12) | <0.001 | 1.29 (1.15–1.42) | <0.001 |
| 2 | 1.0 (Ref) | 1.09 (0.88–1.35) | 1.58 (1.30–1.93) | <0.001 | 1.36 (1.22–1.51) | <0.001 |
| 3 | 1.0 (Ref) | 1.00 (0.89–1.23) | 1.28 (1.15–1.42) | 0.004 | 1.22 (1.08–1.37) | 0.001 |
| 4 | 1.0 (Ref) | 1.01 (0.81–1.27) | 1.27 (1.03–1.57) | 0.01 | 1.19 (1.06–1.34) | 0.004 |
| 5 | 1.0 (Ref) | 1.02 (0.82–1.28) | 1.29 (1.04–1.61) | 0.01 | 1.25 (1.10–1.44) | 0.001 |
Model 1, unadjusted model; Model 2, Model 1 + adjustment for age and sex; Model 3, Model 2 + adjustment for mean arterial blood pressure, the use of antihypertensive drugs, BMI, ethnicity, smoking status, eGFRCKD-EPI and albuminuria; Model 4, Model 3 + adjustment for total cholesterol, history of diabetes, serum phosphate, calcium and plasma PTH, 25(OH)D, hsCRP and 24-h urinary urea excretion; Model 5, Model 4 + adjustment for serum iron, transferrin and ferritin.