Table 4.
Associations of FGF23 with mortality
| Sex-specific tertiles of FGF23 (RU/mL), median (IQR) |
||||||
|---|---|---|---|---|---|---|
| ♂: <61.9 | ♂: 61.9–74.2 | ♂: >74.2 | ||||
| Model | ♀: <58.4 | ♀: 58.4–82.9 | ♀: >82.9 | |||
| Mortality (n = 214) | Ptrend | Log2FGF23 (continuous), median (IQR) | P-value | |||
| 1 | 1.0 (Ref) | 2.02 (1.36–2.98) | 2.62 (1.80–3.82) | <0.001 | 1.31 (1.10–1.55) | 0.002 |
| 2 | 1.0 (Ref) | 1.91 (1.29–2.83) | 2.08 (1.42–3.03) | 0.001 | 1.30 (1.08–1.56) | 0.006 |
| 3 | 1.0 (Ref) | 1.97 (1.60–2.41) | 2.12 (1.73–2.59) | 0.002 | 1.28 (1.06–1.55) | 0.01 |
| 4 | 1.0 (Ref) | 1.97 (1.32–2.94) | 2.01 (1.35–2.99) | 0.004 | 1.25 (1.03–1.52) | 0.03 |
| 5 | 1.0 (Ref) | 1.97 (1.32–2.95) | 1.99 (1.33–2.98) | 0.008 | 1.30 (1.03–1.63) | 0.03 |
Model 1, unadjusted model; Model 2, Model 1 + adjustment for age and sex; Model 3, Model 2 + adjustment for mean arterial blood pressure, the use of antihypertensive drugs, BMI, ethnicity, smoking status, eGFRCKD-EPI and albuminuria; Model 4, Model 3 + adjustment for total cholesterol, history of diabetes, serum phosphate, calcium and plasma PTH, 25(OH)D, hsCRP and 24-h urinary urea excretion; Model 5, Model 4 + adjustment for serum iron, transferrin and ferritin.