Table 4.
The activity of repeated daily doses of crude extract of AIRE on hyperglycemia in STZ-induced diabetic mice.
| Blood glucose level (mg/dl) | |||||
|---|---|---|---|---|---|
| Group | FBGL at baseline | FBGL after 7 days | FBGL after 14 days | R (%) at 7 days | R (%) at 14 days |
| DW10 ml/kg | 391.6 ± 2.249 | 393.8 ± 1.967 | 397.6 ± 4.226 | −0.56 | −1.50 |
| AIRE100 mg/kg | 416 ± 27.817 | 349.4 ± 17.657Axβznx | 338.9 ± 19.530Axβznx | 16.10 | 18.50 |
| AIRE200 mg/kg | 377.4 ± 21.970 | 296.6 ± 11.369Axβznx | 284.4 ± 4.760Ayβznx | 21.40 | 24.60 |
| AIRE400 mg/kg | 393 ± 11.176 | 288.5 ± 9.963Axβzny | 279.8 ± 10.856Axβzny | 26.50 | 28.80 |
| GLC5 mg/kg | 376.4 ± 8.698 | 147.2 ± 3.056AyByCxDxβyny | 129.4 ± 3.429AzByCxDxβzny | 60.80 | 65.60 |
| Normal control | 77.6 ± 7.987 | 77.4 ± 2.966 | 77.2 ± 1.815 | 0.25 | 0.51 |
N = 6 for each treatment; each value is presented in mean ± SEM. ACompared to diabetic control; βcompared to the baseline blood glucose level; Bcompared to 100 mg/kg AIRE; Ccompared to 200 mg/kg AIRE; Dcompared to 400 mg/kg AIRE; ncompared to normal control. xp < 0.05;yp < 0.01; zp < 0.001. DW, distilled water; GLC, glibenclamide; AIRE, Ajuga integrifolia root extract; R, reduction.