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. 2020 Dec 21;2020:8810785. doi: 10.1155/2020/8810785

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Copyright © 2020 Jinghan Zhu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Modulation of system Xc⁻ in ferroptotic cancer cells.The cystine/glutamate exchanger is composed of SLC7A11 and SLC3A2. Inhibition of them both can impair the uptake of cystine and following GSH synthesis, thus affect the activity of GPX4 and sensitize tumor cells to ferroptosis. Cys-Cys: cystine; Cys: cysteine; GSH: glutathione; SLC3A2: solute carrier family 3 member 2; SLC7A11: solute carrier family 7 member 11; MTDH: metadherin; ATF3: activating transcription factor 3; BAP1: BRCA1-associated protein 1; IFNγ: interferon-γ; p53: tumor protein p53; OTUB1: OTU deubiquitinase, ubiquitin aldehyde binding 1; CD44: CD44 molecule (Indian blood group); NRF2: nuclear factor erythroid 2-related factor 2; ARF: also known as CDKN2A: cyclin-dependent kinase inhibitor 2A; BECN1: beclin1; AMPK: also known as PRKAA2: protein kinase AMP-activated catalytic subunit alpha 2.