Table 1.

p53-related ferroptotic genes.

Gene	Name	Function
ALOX12	Arachidonate 12-lipoxygenase, 12S type	A critical regulator of p53-dependent ferroptosis. Deletion of one AlOX12 allele is enough to abrogate p53-mediated ferroptosis [59].
CDKN2A	Cyclin-dependent kinase inhibitor 2A	CDKN2A activation sensitized tumor cells to ROS-induced ferroptosis [36].
DPP4	Dipeptidyl peptidase 4	DPP4 is critical for ferroptosis in p53-deficient colorectal cancer cells [72].
SAT1	Spermidine/spermine N1-acetyltransferase 1	p53-mediated activation of SAT1 sensitized tumor cells to ferroptosis in the presence of ROS stress. Knockdown of SAT1 partially rescued ROS-induced ferroptosis [66].
SOCS1	Suppressor of cytokine signaling 1	Expression of SOCS1 sensitized cells to ferroptosis inducer. This effect of SOCS1 was efficiently blocked by ferroptosis inhibitor. Expression of SOCS1 reduced the levels of GSH, explaining in part its ability to sensitize cells to ferroptosis [37].
SLC7A11	Solute carrier family 7 member 11	Elevated levels of SLC7A11 make cells resistant to erastin-induced ferroptosis. p53 negatively regulates SLC7A11 expression that sensitizes cells to undergo erastin-induced ferroptosis [117].
TP63	Tumor protein p63	Delta Np63 alpha can inhibit ferroptosis independent of p53. Overexpression protects cells from ferroptosis-inducing agents [118].
Mutated p53	Mutated p53 S47	The S47 mutation makes cell significantly resistant to agent-induced ferroptosis [119].
	Mutated p53 3KR	This p53 mutation type losses the ability to induce cell cycle arrest, senescence, and apoptosis, but still has the capability of SLC7A11 inhibition [64].
	p53 4KR98	p53 4KR98 is unable to induce ferroptosis, and its ability to block cancer proliferation is also abolished [117].
	p53 R273H and p53 R175H	These two mutations inhibit SLC7A11 expression by blocking NRF2-mediated SLC7A11 elevation [67–69].