Table 2.

Response criteria used in the evaluation after two cycles of systemic therapy

Response Category	EORTC criteria	Adapted for SAM, norm SAM and TLG
Responders
Complete metabolic response	Disappearance of all lesions	Disappearance of all lesions
Partial metabolic response	Decrease>25% of SUVmax	Decrease>30% of NSAM, norm SAM or TLG
Non-responders
Stable metabolic disease	Increase <25% of SUVmax Decrease <15% of SUVmax No increase of the extension of FDG-uptake	Increase <30% Decrease <30% Of NSAM, NSAM or TLG
Progressive metabolic disease	New lesions Increase>25% of SUVmax	New lesions Increase>30% of NSAM, NSAM or TLG

EORTC European Organisation for Research and Treatment of Cancer, SAM standardized added metabolic activity, NSAM normalized SAM, TLG total lesion glycolysis