Tlr3
−/− mice show lower ethanol intake than Tlr3
+/+ mice in males but not females in the two-bottle choice-every-other-day (2BC-EOD) procedure. (A,D) Ethanol (15 and 20% v/v) consumption (g/kg/24 hours), (B,E) Preference for ethanol (15 and 20% v/v), and (C,F) Total fluid intake (g/kg/24 hours) in male (n = 10 per genotype) and female (n = 9-10 per genotype) mice. Each data point represents the average of two drinking days (measured with two different bottle positions). Drinking days 2-12 show data collected with 15% ethanol, and drinking days 14-22 show 20% ethanol data (*p < 0.05 and **p < 0.01 compared with corresponding Tlr3
+/+ mice).