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Male but not female Tlr3 −/− mice show prolonged duration of loss of the righting reflex (LORR) induced by ethanol and gaboxadol. (A) Duration of ethanol (3.6 g/kg)-induced LORR (min) in male (n = 6 per genotype) and female (n = 5-6 per genotype) Tlr3 +/+ and Tlr3 −/− mice. (B) Duration of gaboxadol (55 mg/kg)-induced LORR (min) in male (n = 5-6 per genotype) and female (n = 6 per genotype) Tlr3 +/+ and Tlr3 −/− mice (****p < 0.0001 compared with corresponding Tlr3 +/+ mice).
