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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Addict Biol. 2020 Jun 30;26(2):e12932. doi: 10.1111/adb.12932

Figure 9.

Figure 9.

Acute functional tolerance (AFT) to ethanol-induced loss of the righting reflex (LORR) is not altered in male Tlr3 −/− or Myd88 −/− mice compared with their corresponding wild-type littermates. (A) Duration of the loss of righting reflex (LORR) after the first (3.5 g/kg) and second (1 g/kg) ethanol injections in Tlr3 +/+ and Tlr3 −/− male mice (n = 8-9 per genotype). (B) Blood ethanol concentrations (BEC) measured at the time of regaining function after the first and second ethanol injections (n = 7-8 per genotype). (C) AFT measured as BEC2 - BEC1 (n = 7-8 per genotype). (D) Duration of the LORR after the first (3.5 g/kg) and second (1 g/kg) ethanol injections in Myd88 +/+ and Myd88 −/− male mice (n = 9-10 per genotype). (E) BECs measured at the time of regaining function after the first and second ethanol injections (n = 9 per genotype). (F) AFT measured as BEC2 - BEC1 (n = 9 per genotype). ****p < 0.0001 compared with corresponding wild-type mice by Bonferroni post-hoc (A, D) tests.