. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: Addict Biol. 2020 Jun 30;26(2):e12932. doi: 10.1111/adb.12932

Table 1.

Summary of responses to ethanol and GABAergic drugs in Tlr3 or Myd88 knockout male and female mice compared with their corresponding wild-type littermates.

Procedure		Tlr3 ^−/− mice		Myd88 ^−/− mice
Procedure		Males	Females	Males	Females
2BC	Ethanol intake	=	=	= ^a	= ^a
	Preference	=	=	= ^a	= ^a
	Total fluid intake	=	=	= ^a	= ^a
2BC-EOD	Ethanol intake	↓, ↓ ^*	=	↑ ^a	= ^a
	Preference	↓, = ^*	=	↑ ^a	= ^a
	Total fluid intake	↑, = ^*	=	= ^a	= ^a
2BC-Limited Access	Ethanol intake	=	=	↑ ^a	= ^a
	Preference	=	=	= ^a	= ^a
	Total fluid intake	=	=	= ^a	= ^a
2BC-Saccharin	Preference	=	=	↓ ^a	= ^a
Acute Withdrawal (HIC)	Ethanol	=	=
CTA	Ethanol	=	=	=	=
CPP (Acquisition)	Ethanol	↑	=	=	=
Rotarod Ataxia	Ethanol	→	=	← ^a	← ^a
Rotarod Ataxia	Diazepam	→	=	← ^a	← ^a
LORR	Ethanol	↑	=	↓ ^b	↓ ^b
LORR	Gaboxadol	↑	=	↓ ^b	↓ ^b
AFT (Rotarod)	Ethanol	↓		↑
Clearance	Ethanol (4 g/kg)	=	=		= ^b
Clearance (before and after 2BC-EOD)	Ethanol (2 g/kg)	=

=, no change; ↑ (increased) versus ↓ (decreased) response; → (longer) versus ← (shorter) recovery from motor impairing effects of ethanol or diazepam.

From different groups of 2BC-EOD exposed male mice (see Figures 1 and 11).

From Blednov et al. (2017)⁶ and

from Blednov et al. (2017).⁵

2BC, two-bottle choice; 2BC-EOD, two-bottle choice every-other-day; AFT, acute functional tolerance; CPP, conditioned place preference; CTA, conditioned taste aversion; HIC, handling-induced convulsion; LORR, loss of the righting reflex.