Table 1:

Select PD-relevant genes involved in vesicle trafficking and/or lipid homeostasis. Dark green indicates more direct aspects, light green more indirect aspects.

Gene/Protein ([reference]	Connection to vesicle trafficking/function	Connection to lipid homeostasis
SNCA/αS [see section 1]	- binds to (small) vesicles - KD and OE affect synaptic trafficking - OE affects somatic trafficking	binds to membrane lipids may bind to free FAs may affect lipid metabolism
GBA/GCase [79]	important for lysosome function	key enzyme in glycolipid catabolism
SCARB2/LIMP2 [84, 116]	chaperone for GBA trafficking	Indirect effect on lipids via GBA
LRRK2 [94, 154]	regulates endocytic/lysosomal/ER-Golgi trafficking	may affect LD biology
RAB29/RAB7-L [56]	endosomal Rab GTPase	may affect LD biology
RAB39B [142]	Endosomal/lysosomal/Golgi Rab GTPase	may affect LD biology
VPS35 [153]	retromer subunit; affects endosomal sorting	may affect LD biology
VPS13C [84]	endosomal sorting	may affect LD biology
ATP6AP2 [64]	ATPase cation transporter, lysosome	may affect lysosomal steps of lipid biology
ATP13A2 [101]	ATPase cation transporter, lysosome	may affect lysosomal steps of lipid biology
SYT11/Synaptotagmin-11 [1]	regulates lyso/autophagosome fusion; exocytosis	may affect LD biology
SYNJ1/Synaptojanin-1 [92]	regulates synaptic endocytosis	phospholipase; affects lipid headgroups
DNAJC6/Auxilin-1 [43]	neuron-specific clathrin-uncoating chaperone	?
PLA2G6 [83]	indirect effects via membrane lipid composition	phospholipase; affects lipid headgroups
SREBF-1 [41]	indirect effects via membrane lipid composition	transcription factor; regulates sterol synthesis
ELOVL7/FA-Elongase 7 [17, 69]	indirect effects via membrane lipid composition	affects chain length of membrane lipids
DGKQ [20, 84]	indirect effects via membrane lipid composition	diacylglycerol kinase; affects lipid headgroups