Figure 8.

Myeloid-specific deletion of IL-1α does not alter respiratory quotient, energy expenditure, activity, sleep time, or caloric intake. (A) Respiratory quotient (RQ) at daily intervals showing light cycle (white) or dark cycle (grey). (B) Mean RQ across all time points over a 7-d period. (C) Energy expenditure (EE) at daily intervals and (D) mean EE. (E) Total food consumed in a 7-d period (g) and (F) total liquid consumed in a 7-d period (g). n = 8 per group. (G) Schematic illustrating that IL-1R activation by IL-1β (initial signal) drives the production of IL-1α. IL-1α (secondary signal) supports both insulin secretion and growth of endocrine and exocrine tissue (not pictured), while conceivably also influencing the status of tissue resident immune cells. The question mark indicates that a specific type of action (e.g., change in gene expression, chemotaxis, etc.) on tissue resident immune cells is not established at present.