Table 1.
Top GO groups enriched for differential expression in areas of AD-associated hypometabolism in brain 10 021/H0351.2002
| Name | Genes | ID | AUC | p valueFDR |
|---|---|---|---|---|
| SRP-dependent cotranslational protein targeting to membrane | 87 | GO:0006614 | 0.874 | 1.35E-29 |
| Cotranslational protein targeting to membrane | 90 | GO:0006613 | 0.865 | 2.07E-29 |
| Protein targeting to ER | 92 | GO:0045047 | 0.847 | 2.86E-27 |
| Cytosolic ribosome | 87 | GO:0022626 | 0.856 | 3.45E-27 |
| Establishment of protein localization to endoplasmic reticulum | 96 | GO:0072599 | 0.828 | 1.66E-25 |
| Structural constituent of ribosome | 107 | GO:0003735 | 0.794 | 1.05E-22 |
| Ribosomal subunit | 158 | GO:0044391 | 0.737 | 1.01E-21 |
| Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 104 | GO:0000184 | 0.783 | 2.07E-20 |
| Protein localization to endoplasmic reticulum | 109 | GO:0070972 | 0.765 | 9.44E-19 |
| Cytosolic large ribosomal subunit | 47 | GO:0022625 | 0.894 | 6.73E-18 |
| microtubule organizing center part | 145 | GO:0044450 | 0.395 | 0.00244 |
| DNA-dependent ATPase activity | 59 | GO:0008094 | 0.33 | 0.00145 |
| HOPS complex | 13 | GO:0030897 | 0.137 | 0.00135 |
| ATPase activity, coupled | 186 | GO:0042623 | 0.396 | 0.00026 |
| tRNA aminoacylation for protein translation | 40 | GO:0006418 | 0.268 | 9.84E-05 |
| Amino acid activation | 43 | GO:0043038 | 0.275 | 8.24E-05 |
| Aminoacyl-tRNA ligase activity | 33 | GO:0004812 | 0.243 | 8.24E-05 |
| Cullin-RING ubiquitin ligase complex | 111 | GO:0031461 | 0.355 | 3.84E-05 |
| tRNA aminoacylation | 42 | GO:0043039 | 0.259 | 1.91E-05 |
| Ubiquitin ligase complex | 195 | GO:0000151 | 0.368 | 7.35E-08 |