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. 2020 Dec 30;86(3):257–261. doi: 10.1134/S0006297921030032

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© The Author(s) 2020

Open access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Figure. — Putative involvement of free S1 subunits of the SARS-CoV-2 S protein in the COVID-19 infection. Spontaneous “firing” of the S protein trimers on the surface of virions and infected cells liberates free RBD-containing S1 particles. The binding of these S1 particles to ACE2 may cause a decrease in the ACE2 cell surface expression and lead to the RAS imbalance.