Fig. 1.

UCLH PROMIS cohort (n = 235). Men were classified according to mpMRI findings (Likert scores) and TPM biopsy results to four categories, as shown in the organogram: (1) no cancer, (2) insignificant cancer, (3) definition 1 cancer, and (4) definition 2 cancer. There was a significant difference in presenting PSAD between the four TPM groups (p < 0.001, Kruskal-Wallis ANOVA). In total, 178 out of 235 men (76%) had at least one lesion in their prostate and were the focus of subsequent analyses. ANOVA = analysis of variance; Ca = cancer; mpMRI = multiparametric magnetic resonance imaging; PROMIS = Prostate MRI Imaging Study; PSAD = prostate-specific antigen density; TPM = transperineal mapping biopsy; UCLH = University College London Hospital.