Fig. 2.

MRI lesion count, conspicuity, distribution, and focality in the UCLH PROMIS cohort. More men with any significant cancer had more than one lesion (77/115 or 67%) than those without significant disease (23/63 or 37%, p <  0.001; see the table). (A) The proportion of index lesions with high conspicuity (Likert score 4–5) increased with significant cancer burden and was significantly higher in men with significant cancer (91/115, 79%) than in those without significant disease (14/63, 22%; p <  0.001). (B) Index lesions were predominantly distributed in the PZ across all groups. (C) MRI lesions characterised by the uroradiologist as “diffuse” were more common in the TPM-negative/insignificant disease groups collectively than in men with significant disease, although this difference was not statistically significant. Ca = cancer; MRI = magnetic resonance imaging; PROMIS = Prostate MRI Imaging Study; PZ = peripheral zone; TPM= transperineal mapping biopsy; TZ = transition zone.