Fig. 3.

Basic radiomic characteristics of mpMRI lesions across TPM groups in the UCLH PROMIS cohort. (A) As the burden of significant disease on TPM increased, so did Likert scores for all mpMRI sequences; however, there was also a gradual shift from predominantly T2W + DWI–DCE + MRI phenotypes in men without significant cancer to T2W++DWI+++DCE++ lesions in those with significant disease. (B and C) Lesion ADC values decreased with increasing disease burden (ADC distributions shown; two outliers removed for visualisation purposes), but this reduction was particularly marked for index lesions. (D and E) Lesion volumes were greater and more skewed in men with definition 1 disease (volume distributions shown; seven outliers removed for visualisation purposes), particularly in the case of index lesions. (F) There was a positive relationship between lesion volume and PSAD, especially in men with significant cancer (regression lines shown for men with/without significant disease). ADC = apparent diffusion coefficient; Ca = cancer; DCE = dynamic contrast enhanced; DWI = diffusion-weighted imaging; mpMRI = multiparametric MRI; MRI = magnetic resonance imaging; PROMIS = Prostate MRI Imaging Study; PSAD = prostate-specific antigen density; TPM = transperineal mapping biopsy; T2W = T2 weighted.