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. 2020 Dec 30;10:148. doi: 10.1186/s13578-020-00519-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — ACE2 SNPs associated diseases reported in meta-analyses. 11 genetic variants are represented by different colors and have been associated with different diseases; rs2285666 and rs2106809 are the most frequent genetic variants, rs2285666 is correlated with essential hypertension, HDL-C, hsCRP, IMT and pulse pressure and rs2106809 is linked to diabetes mellitus (type 2), atrial fibrillation and hypertrophic cardiomyopathy. This figure was created using Server Medical Art templates, which are licensed under a Creative Commons Attribution 3.0 Unported License; https://smart.servier.com