Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Bacterial PAMPs that cause nociception. Cell wall components of Gram-negative bacteria, including Lipopolysaccharide (LPS), can activates nociceptors through either neuronal TLR4 or direct signaling to the transient receptor potential cation channel subfamily A member 1 (TRPA1) ion channel. Gram-negative bacteria can also activate nociceptors through binding of bacterial flagellin to TLR5, however it is unclear how that leads to neuronal activation. Image created with BioRender.com.
