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. 2020 Dec 24;14:100286. doi: 10.1016/j.ynstr.2020.100286

Fig. 6.

Fig. 6

LTP is impaired only in susceptible mice identified through the AIS model.(A) Experimental design. On the right, cartoon representing electrodes placement within the hippocampal slice. (B) No differences in fEPSP slope or fiber volley (FV) are found when analyzing Basal Synaptic Transmission (BST) in control (n = 9 slices from 6 animals), resilient (n = 9 slices from 6 animals) and susceptible mice (n = 9 slices from 7 animals). (C) Long-Term Potentiation (LTP) is not impaired in resilient mice (234.68 ± 7.52 vs. 228.26 ± 13.77% of baseline; n = 7/8 slices from 6/7 animals), whereas it is impaired in susceptible mice (155.94 ± 15.72% of baseline; Stresssusceptibility, F(1,13) = 16.505, P = 0.001, n = 9 slices from 7 animals). On top: representative traces of recoded fEPSPs comparing baseline (light grey) and last recording point (colored). (D) Residual potentiation (average of the last 5 min of LTP recording at 120 min after tetanus) analysis confirms the LTP impairment in susceptible mice (Stresssusceptibility, F(2,21) = 9.403, P = 0.001 among all; controls: 231.39 ± 7.35% of baseline; resilient: 218.94 ± 12.60% of baseline; susceptible: 154.41 ± 15.72% of baseline). (E) Triangular surface plot representing the individual traces of LTP recordings for each slice from control, (F) resilient, and (G) susceptible mice. Two-way repeated measures ANOVA or One-way ANOVA. Bonferroni post hoc test: *P < 0.05. Values are expressed as means ± s. e.m.