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. 2020 Dec 24;14:100286. doi: 10.1016/j.ynstr.2020.100286

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 7 — Chronic treatment with paroxetine was effective in susceptible mice but detrimental in control and resilient mice.(A) Experimental timeline designed for the assessment of the effect of chronic treatment with paroxetine in control (vehicle n = 8, paroxetine n = 7), susceptible (vehicle n = 7, paroxetine n = 6) and resilient mice (vehicle n = 7, paroxetine n = 8). (B) Startle magnitude (% of baseline) (Day 36: Treatment, F_{(1, 37)} = 6.024, P = 0.019; Stresssusceptibility, F_{(2, 37)} = 18.88, P < 0.0001. Day 43: Treatment, F_{(1, 37)} = 3.84, P = 0.049; Stresssusceptibility, F_{(2, 37)} = 14.25, P < 0.0001). (C) Startle latency (% of baseline) (Day 36: Treatment, F_{(1, 37)} = 12.02, P = 0.0014; Stresssusceptibility, F_{(2, 37)} = 6.64, P = 0.0034. Day 43: Stresssusceptibility, F_{(2, 37)} = 5.271, P = 0.0097). (D) AROUSAL score (Treatment, F_{(1, 37)} = 8.67, P = 0.0056; Stresssusceptibility, F_{(2, 37)} = 22.23, P < 0.0001). (E) Center entries ratio (Treatment x Stresssusceptibility F_{(2, 37)} = 10.45, P = 0.0003) and (F) time spent in center of the OF (Treatment x Stresssusceptibility F_{(2, 37)} = 7.45, P = 0.0019). (G) Entries in open arms (Treatment F_{(1, 37)} = 25.14, P < 0.0001; Treatment x Stresssusceptibility F_{(2, 37)} = 22.68, P < 0.0001) and (H) time in open arms of EPM (Treatment F_{(1, 37)} = 5.29, P = 0.0272; Treatment x Stresssusceptibility F_{(2, 37)} = 8.77, P = 0.0008). (I). AVOIDANCE-like score (Treatment F_{(1, 37)} = 18.3, P < 0.0001; Treatment x Stresssusceptibility F_{(2, 37)} = 30.48, P < 0.0001). (J) Social duration during the 5-trial SM test [Treatment x trial, F_{(20, 144)} = 3.065, P < 0.0001; Trial, F_{(4, 144)} = 74.6, P < 0.0001. Bonferroni post hoc test: *p < 0.05, ***p < 0.001 vs each specific trial 1 (habituation); †p < 0.05, ††p < 0.01, †††p < 0.001 vs each specific trial 5 (dishabituation)]. (K) SOCIAL MEMORY score (Treatment x Stresssusceptibility F_{(2, 37)} = 8.69, P = 0.0008). (L) PTSD-like score 2 (Treatment F_{(1, 37)} = 15.05, P = 0.0004; Stresssusceptibility F_{(2, 37)} = 14.31, P < 0.0001; Treatment x Stresssusceptibility F_{(2, 37)} = 17.45, P < 0.0001). Two-way ANOVA or one-way ANOVA followed by Bonferroni post hoc test *P < 0.05, **P < 0.01, ***P < 0.001 vs vehicle-treated control mice, &P < 0.05, &&P < 0.01, &&&P < 0.001 vs vehicle-treated susceptible mice, #P < 0.05, ##P < 0.01, ###P < 0.001 vs vehicle-treated resilient mice. Values are expressed as means ± s. e.m.