Table 2:

Arsenic-induced miRNA changes in in vivo models

Animal Strain, Tissue	Arsenic Concentration & Time of Exposure	Results	miRNA Findings	Reference
Wistar, liver	5 mg/kg bw, 14 and 28 days	Liver toxicity and increased oxidative stress	Up: miR-let7a, after 14 days Down: miR-let7a, after 28 days, miR-146a	[56]
Sprague-Dawley, liver	0.1, 1, 10, or 100 mg/L sodium arsenite, 60 days	Alteration of hepatic glutamate–cysteine ligase activity and glutathione levels	Up: miR-151, miR-183, miR-148b and miR-192 Down: miR-26a, miR-423	[57]
C3H mice, liver	Transplacental exposure to 42.5 and 85 ppm, gestational days 8–19	Differential DNA methylation	50 miRNAs altered at 42.5 ppm and 140 at 85 ppm Validated-Up: miR-205, miR-203, miR-215, miR-34a Down: miR-217	[59]
ApoE−/− mice, liver	Transplacental exposure to 85 mg/L, gestational day 8 to birth	Increased expression of inflammatory cytokine and heat shock protein 70. Elevated SREBP1 expression, and liver enzymes in plasma	PND1 – Up: miR-361, miR-148a, miR-467a Down: miR-let-7d, miR-719, miR-679, miR-592, miR-222, miR-497, miR-211, miR-188 PND70 – Up: miR-211, miR-291a-5p-291b-5p, miR-294, miR-302, miR-464 Down: miR-1, miR-10a, miR-15b, miR-214a, miR-130a, miR-149, miR-186, miR-193, miR-218, miR-337, miR-376a, miR-412, miR-476b, miR-681, miR-715	[63]