Table 3.

Evaluation of prognostic indices according to usability and time frame of mortality outcome.

Author (Year)	Population (Country)	Outcome	Where to find Risk Tool and Scoring	Variables included in the prognostic index†
Clinically Usable‡
1. Hippisley-Cox & Coupland (2017)22	Primary care patients aged 65 or older (England)	1-year all-cause mortality	Instrument and scoring information not found in article. QMortality®−2017 risk calculator (https://qmortality.org/, accessed April 30, 2019)	Demographics: age, ethnic group Medications: antipsychotics, corticosteroids Social history: alcohol intake, smoking status, living in a care home, Vital signs/labs: abnormal liver function test result, anemia, body mass index, high platelet count Medical diagnosis: asthma or chronic obstructive pulmonary disease, atrial fibrillation, cancer, cardiovascular disease, chronic kidney disease, chronic liver disease or pancreatitis, congestive heart failure, dementia, diabetes type 1, diabetes type 2, epilepsy, learning disability, leg ulcer, Parkinson’s disease, rheumatoid arthritis, venous thromboembolism Functional measures: Townsend deprivation score, poor mobility Other: unplanned hospital admissions in the past 12 months, visits to a general practitioner in the past 12 months with either appetite loss, unexplained weight loss, or dyspnea
2. Gagne et al. (2011)26	Medicare enrollees aged 65 years or older (USA)	1-year all-cause mortality	Instrument is presented in Table 3 and how to interpret score in bottom panel Figure 2.26 Gagne Index (https://eprognosis.ucsf.edu/gagne.php, accessed April 30, 2019)	Medical diagnosis: alcohol abuse, deficiency anemia, any tumor, cardiac arrhythmias, chronic pulmonary disease, coagulopathy, complicated diabetes, congestive heart failure, dementia, fluid and electrolyte disorders, hemiplegia, HIV/AIDS, hypertension, liver disease, metastatic cancer, peripheral vascular disorder, psychosis, pulmonary circulation disorders, renal failure, weight loss
3. Mazzaglia et al. (2007)27	Community-dwelling adults aged 65 years and older (Italy)	15-month all-cause mortality	Instrument and how to interpret score are partially available in the article (Table 2 and Figure 1A).27 Authors do not state how to score the 7-item screening test (p. 1956). Mazzaglia Index (https://eprognosis.ucsf.edu/mazzaglia.php, accessed April 30, 2019)	Demographics: age, sex Medications: ≥5 prescription medications Functional measures: positive responses to a screening test45 (need help in performing basic ADL, need help in performing IADL, poor vision, poor hearing, weight loss, use of homecare services, and self-perceived inadequacy of income) Other: hospitalization in the previous 6 months
4. Carey et al. (2004)28	Frail community-dwelling adults aged 70 years and older (USA)	2-year all-cause mortality	Instrument in Table 3 and interpretation of scoring in Table 4.28 Carey 2 Year Index (https://eprognosis.ucsf.edu/carey2.php, accessed April 30, 2019)	Demographics: age, sex Functional measures: dependence in bathing, dependence in shopping, difficulty walking several blocks, difficulty pulling/pushing heavy objects
5. Carey et al. (2008)30	Community-living patients aged 75 years and older enrolled in the Program of All-Inclusive Care for the Elderly (USA)	1-, 2-, and 3-year all-cause mortality	Instrument in Table 3 and interpretation of scoring in Table 4.30 Carey 3 index available online (https://eprognosis.ucsf.edu/carey3.php, accessed April 30, 2019)	Demographics: age, male sex Medical diagnosis: congestive heart failure, COPD, malignant neoplasm, renal failure or insufficiency Functional measures: dependence in toileting, dependence in dressing
6. Lee et al. (2006)31	Community-dwelling adults aged 50 years and older (USA)	4-year all-cause mortality	Instrument available in the article (Box on p. 807), score interpretation Table 4.31 Calculator online (https://eprognosis.ucsf.edu/lee.php, accessed April 30, 2019)	Demographics: age, male sex Social history: current smoker Vital signs/labs: BMI < 25 Medical diagnosis: diabetes mellitus, cancer, lung disease, heart failure, Functional measures: bathing, managing finances, walking several blocks, pushing/pulling heavy objects
7. Ganna & Ingelsson (2015)33	Community-based participants aged 40 to 70 years (UK)	5-year all-cause mortality	Instrument available online, but not in the article. (https://www.ubble.co.uk/risk-calculator/, accessed April 30, 2019)	Women Demographics: age, gender Social history: financial assistance, smoking history Medical diagnosis: cancer Functional measures: disability or infirmity, usual walking pace, Other: number of live births, presence of long-standing illness, self-rated overall health, serious life events in the last 2 years, visit with a general practitioner for nerves, anxiety, tension or depression Men Demographics: age, gender Social history: financial assistance, number of vehicles owned in a household, number of people living in house, relatedness of people living in house, smoking history Medical diagnosis: diabetes, cancer, history of heart attack, angina, stroke, or high blood pressure Functional measures: usual walking pace Others: self-rated overall health, serious life events in the last 2 years
8. Mathias et al. (2013)34	Outpatients aged 50 years and older (USA)	5-year all-cause mortality	Instrument available online, but not in the article. (http://info.eecs.northwestern.edu/FiveYearLifeExpectancyCalculator, accessed September 2019)	Demographics: age, sex Medications: digoxin prescription, loop diuretic prescription Vital signs/labs: mean diastolic blood pressure, albumin – mean, median, standard deviation for the prior year, creatinine – mean, median, standard deviation for the prior year Medical diagnosis: any vascular disease, heart failure, hypertension, chronic kidney disease, diabetes mellitus, dementia, HIV, anemia, any cancer, any liver disease Functional measures: number of visits to primary care provider in the year prior to the index visit, number of hospitalizations 0–1 years prior, number of hospitalizations 1–2 years prior
9. Zhang et al. (2012)36	Community-dwelling elderly population aged 70 years and older (USA)	1- and 5-year all-cause mortality	Instrument and scoring available in the article (Figures 1 and 2).36	1-year Demographics: age, gender Medical diagnosis: coronary artery disease Functional measures: IADL stage 5-year Demographics: age, gender Medical diagnosis: cancer, coronary artery disease, diabetes, other heart disease Functional measures: IADL stage Other: self-rated health status
10. Schonberg et al. (2009)37	Community-dwelling adults aged 65 and older (USA)	5-year all-cause mortality	Instrument available in the article (Table 2) and scoring in Table 3.37 Available online (https://eprognosis.ucsf.edu/leeschonberg.php, accessed April 30, 2019)	Demographics: age, male sex Social history: smoking status Vital signs/labs: body mass index < 25 Medical diagnosis: cancer, emphysema/chronic bronchitis, diabetes mellitus Functional measures: needs help of other persons handling routine needs, difficulty walking Others: overnight hospitalizations in past year, perceived health
Not usable‡
11. Duarte et al. (2015)21	Primary and tertiary care patients aged 65 years and older (USA)	6-month all-cause mortality	Instrument available in the Appendix (self-reported patient questionnaire)21; scoring not shown.	Demographics: age, sex Social history: proxy status, smoking status Medical diagnosis: any cancer, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) Functional measures: activities of daily living (ADLs), health-related quality of life (HRQOL)
12. Han et al. (2012)20	Medicare Health Outcomes Survey respondents aged 65 years or older (USA)	6-month all-cause mortality	Not in article or online.	See Duarte et. al (2015)21
13. Crooks et al. (2016)23	Primary and secondary care patients aged 20 years and older (England)	1-year all-cause mortality	Not in article or online.	Social history: alcohol or illegal drug use Medical diagnosis: burns, chromosomal anomalies, cerebrovascular disease, chronic obstructive pulmonary disease (COPD), cirrhosis, dementia, diabetes, epilepsy, esophageal, heart conduction disorders, heart failure, interstitial lung disease, liver disease, lung disease due to external agents, malignancy of respiratory tract and intrathoracic organs, malignancy of lymphatic and hematopoietic tissue, metastases, neoplasm histology, nephritis, nephrosis and nephrotic syndrome, non-deficiency and non-hemolytic anemias, non-malignant white cell, non-organic psychoses, other central nervous system disorders, platelet and splenic disorders, paralysis, Parkinson’s disease, spinal disease, peripheral vascular disease, pleural disease, stomach and duodenal diseases
14. Pilotto et al. (2013)24	Community-dwelling adults aged 65 years and older (Italy)	1-year all-cause mortality	A link to download free software program in Italian available in the article but must know Italian. (http://www.operapadrepio.it/impi/svamasetup.exe, accessed April 2019)	Demographics: age, sex Social history: nursing care needs, social support network Functional measures: Barthel Index (ADL and mobility) Others: Short Portable Mental Status Questionnaire, Exton-Smith Scale for pressure ulcer
15. Wang et al. (2013)25	Primary care patients of the Veterans Health Administration aged 18–110 years (USA)	1-year all-cause mortality	Not in article or online.	Demographics: age, sex Medications: alpha-blockers, Antidepressants, antiplatelet, angiotensin converting enzyme inhibitor/angiotensin receptor blocker, anticholinergics, antipsychotics, benzodiazepines, beta-agonists, beta-blockers, bumetanide, calcium channel blockers, digoxin, furosemide, HMG-CoA inhibitors, other hypertension drugs, insulin, metformin, metolazone, nitrate long lasting, nitrate short lasting, opioid narcotics, non-steroidal anti-inflammatory drug, non-statin lipid lowering agents, thiazolidinediones, potassium-sparing diuretic, oral steroids, sulfonylureas, diuretic combinations, torsemide, warfarin Social history: substance abuse Vital signs/labs: albumin, blood pressure (diastolic), blood pressure (systolic), blood urea nitrogen, BMI, creatinine, diastolic blood pressure, systolic blood pressure, heart rate, respiration, potassium, white blood cell count Medical diagnosis: acute myocardial infarction, old myocardial infarction, unstable angina, stroke, hemiplegia, Atherosclerosis, depression, heart failure, respiratory failure, valvular heart disease, diabetes, hypertension, COPD, pneumonia, peripheral vascular disease, metastatic cancer, psychotic disorder, liver disease, atrial fibrillation, post-traumatic stress disorder, mental disorder Other: malnutrition, function disease, trauma, coronary artery bypass graft surgery, enrollment priority group 1–8, Deyo-Charlson index, emergency room visits in the past year, cardiology visit in the past year, service connection ≥50%, number of providers, primary care visits in the past year, phone visits in the past year, other non-face visits in the past year, outpatient visits in the past year, mental health hospitalization in the past year, all hospitalization, number of medication refills
16. Turusheva et al. (2017)29	Community-dwelling adults aged 65 years and older (Russia)	3-year all-cause mortality	Instrument in Box 1.29 Interpretation unclear. Instrument in Box 1.29 Interpretation unclear.	Model 1 Demographics: age, male sex Vital signs/labs: anemia, forced expiratory volume in 1 second (FEV1)/[Height(Ht)3], mid-arm muscle area (MAMA) Functional measures: Short physical performance battery (SPPB) Model 2 Demographics: age, male sex Vital signs/lab: brain natriuretic peptide (hBNP), anemia, C-Reactive Protein (CRP), MAMA, FEV1/Ht3 Functional measures: SPPB
17. Jung et al. (2016)32	Community-dwelling adults aged 65 years and older (South Korea)	3- and 5-year all-cause mortality	Application for mobile devices is available for download in Korean (personal communication with authors).	Demographics: age, gender Functional measures: activities of daily living (ADLs), instrumental activities of daily living (IADLs) Other: Charlson Comorbidity Index or Cumulative Illness Rating Scale for Geriatrics, Korean version of the Geriatric Depression Scale, Korean Mini-Mental State Examination, Mini Nutritional Assessment or Nutrition Screening Initiative
18. Tan et al. (2013)35	Medicare beneficiaries aged 66–90 years (USA)	1- and 5-year all-cause mortality	Not in article or online.	Demographics: age Social history: alcohol abuse, drug abuse Medical diagnosis: acquired immunodeficiency syndrome, cardiac arrhythmia, chronic pulmonary disease, chronic blood loss anemia, coagulopathy, congestive heart failure, deficiency anemia, depression, diabetes without chronic complications, diabetes with chronic complications, fluid and electrolyte disorders, hypertension (uncomplicated), hypertension (complicated), hypothyroidism, liver disease, lymphoma, metastatic cancer, neurological disorders other than paralysis, obesity, paralysis, peptic ulcer disease excluding bleeding, peripheral vascular disease, psychoses, pulmonary circulation disease, renal failure, rheumatoid arthritis/collagen vascular disease, solid tumor without metastasis, valvular disease, weight loss

^†Not shown if the prognostic index did not have variables in one of the major categories (demographics, medications, social history, vital signs/labs, medical diagnosis, functional measures, other).

^‡Clinically usable if the mortality risk can be calculated using the instrument and interpreted using tables and/or figures in the paper without referring to the main text in the article, and ‘Not usable’ otherwise or if risk calculator is in a language other than English.