Table 1.
Characteristics of the studies included.
| References | Country (center) | Study type | Recruitment period | N0 of LT cases | Etiology of the underlying liver disease* | Sarcopenia | Obesity | Sarcopenic obesity | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Imaging techniques | Index | Cut-off | Index | Cut-off | |||||||
| Carias et al. (28) | The US (single center) | Retrospective cohort | 2008–2013 | 207 | Alcohol: 25% HCV: 23% NASH: 22% HCC: 25% |
CT scan at the level of the L3 vertebra or DEXA | SMI | <38.5 cm2/m2 for females and <52.4 cm2/m2 for males | BMI | ≥30 kg/m2 | 13% |
| Itoh et al. (23) | Japan (single center) | Retrospective cohort | 2001–2012 | 153 | HCV: 72% HCC: 100% |
CT scan at the level of the L3 vertebra | SMI | Not reported | VFA | Not reported | 33% |
| Kamo et al. (24) | Japan (single center) | Retrospective cohort | 2008–2016 | 277 | HCV: 33.6% NASH: 4% Biliary atresia: 20% Other: 31.4% HCC: 27% |
CT scan at the level of the L3 vertebra | SMI | <40.31 cm2/m2 for males and <30.88 cm2/m2 for females | VFA and BMI | ≥100 cm2 for VFA, ≥25 kg/m2 for BMI | 25% |
| Montano-Loza et al. (20) | Canada (single center) | Retrospective cohort | 2000–2013 | 678 | Alcohol: 25% HCV: 43.3% HBV: 6.9% NASH: 15.5% AIH: 8.9% Other:0.8% HCC: 43% |
CT scan at the level of the L3 vertebra | SMI | <41 cm2/m2 for females and <53 cm2/m2 for males | BMI | ≥25 kg/m2 | 20% |
*
The sum of etiologies exceeds 100% due to the overlap between the different causes of liver transplantation. Bold highlights indicate the proportion of HCC in the study population. AIH, autoimmune hepatitis; BMI, body mass index; CT, computed tomography; DEXA, dual-energy x-ray absorptiometry; HBV, hepatitis B virus; HCV, hepatitis C virus; HCC, hepatocellular carcinoma; LT, liver transplantation; NASH, non-alcoholic steatohepatitis; SMI, skeletal muscle mass index; VFA, visceral fat area.