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. 2020 Dec 14;11:590598. doi: 10.3389/fphar.2020.590598

TABLE 1.

Screened drugs with potential for prophylaxis studies, and their correspondent number of citations and mechanism of action.

Drug Citations Mechanism of action
1 Aciclovir World Health Organization (2020) Nucleoside analog
2 Amantadine World Health Organization (2020) Interferes with transmembrane M2 protein
3 Amprenavir World Health Organization (2020) Protease inhibitor (HIV)
4 Baloxavir marboxil Xie et al. (2020) Endonuclease inhibitor—inhibits the initiation of mRNA synthesis
5 Darunavir Zhang et al. (2020) Second generation protease inhibitor
6 Entecavir World Health Organization (2020) Guanine analogue (HCV)
7 Faldaprevir World Health Organization (2020) HCV protease inhibitor
8 Faviparivir Beigel et al. (2019) Prodrug of a purine nucleotide, favipiravir ribofuranosyl-5′-triphosphate—RNA polymerase inhibitor
9 Galidesivir Mayer et al. (2015) Protease inhibitor—Adenine analog
10 GS-441524 Xie et al. (2020) Adenisin nucleoside analog
11 Indinavir World Health Organization (2020) HIV protease specific inhibitor
12 Lopinavir Beigel et al. (2019) Aspartic acid protease (HIV) inhibitor
13 Nelfinavir Vellingiri et al. (2020) Protease inhibitor
14 Oseltamivir Vellingiri et al. (2020) Active neuraminidase inhibitor
15 Pleconaril Xie et al. (2020) Viral capsid inhibitor
16 Remdesivir Cheng (2019) Prodrug—active nucleoside analog C-adenosine triphosphate—(Ebola)
17 Ribavirin Kang et al. (2020) Nucleoside analogue (guanine)—inhibits viral RNA-dependent RNA polymerase
18 Sofosbuvir Glushkov et al. (1999) Nucleoside analog—hepatitis C virus NS5B polymerase inhibitor
19 Tenofovir Glushkov et al. (1999) Acyclic nucleoside analog adenosine monophosphate
20 Tipranavir Xie et al. (2020) HIV protease enzyme inhibitor
21 Umifenovir Zhou et al. (2020) Hemagglutinin inhibitor (influenza)
22 Zanamivir World Health Organization (2020) Neuraminidase inhibitor