Table 2.
Histopathology and treatment details of retinoblastoma patients presenting at age 6 years or older
| No | Histopathology findings | Surgery | CT cycles | RT | Outcome/follow-up |
|---|---|---|---|---|---|
| Stage 0 | |||||
| 1 | NA | – | 10 | – | AND/79.5 months |
| 2 | NA | – | 9 | – | AND/45 months |
| 3 | No HRF | Enucleation (post-CT) | 7 | – | AND/16.5 months |
| Stage I | |||||
| 4 | Massive choroidal invasion, scleral invasion | Enucleation | 6 | – | AND/93 months |
| 5 | No HRF | Enucleation | 7 | – | AND/8 months |
| 6 | Massive choroidal invasion, post-laminar optic nerve invasion | Enucleation | 6 | – | AND/15 months |
| 7 | Prelaminar optic nerve invasion | Enucleation | 6 | – | AND/51.5 months |
| 8 | Focal choroidal invasion, post-laminar optic nerve invasion | Enucleation | 6 | – | AND/46.5 months |
| 9 | Massive choroidal invasion, scleral invasion | Enucleation | 6 | – | AND/43 months |
| 10 | Post-laminar optic nerve invasion | Enucleation | 6 | – | AND/6 months |
| 11 | Anterior chamber invasion, iris invasion, ciliary body invasion, massive choroidal invasion, scleral invasion | Enucleation | 6 | + | AND/44 months |
| 12 | No HRF | Enucleation | – | – | AND/40.5 months |
| 13 | Prelaminar optic nerve invasion | Enucleation | 3 | Alive with partially regressed tumor in remaining eye/10.5 months | |
| 14 | Prelaminar optic nerve invasion | Enucleation | – | – | AND/37.5 months |
| 15 | Iris invasion | Enucleation | 6 | – | AND/32.5 months |
| 16 | No HRF | Enucleation | – | – | AND/30.5 months |
| 17 | Focal choroidal invasion, post-laminar optic nerve invasion | Enucleation | 5 | – | Orbital and CNS relapse/15 months |
| 18 | No HRF | Enucleation | 8 | – | AND/16.5 months |
| 19 | No HRF | Enucleation (post-CT) | 6 | – | AND/15.5 months |
| 20 | Focal choroidal invasion, post-laminar optic nerve invasion | Enucleation | 6 | – | AND/13 months |
| 21 | Focal choroidal invasion, post-laminar optic nerve invasion | Enucleation | 6 | – | AND/12 months |
| 22 | Large areas of tumor necrosis, calcification, sclera, choroid markedly thickened, enmeshed uveal tissue and atrophic optic nerve | Enucleation (post-CT) | 6 | Alive/84 months | |
| 23 | Descmets membrane invasion, invasion of choroid | R enucleation | 6 | – | Alive/48 months |
| 24 | Poorly differentiated large areas of necrosis and calcification (synaptophysin and NSE positive) | Enucleation | 6 | + | Alive/96 months |
| 25 | Thickened sclera, choroid, sclera and enmeshed uveal tissue free of tumor | Enucleation (post-CT) | 9 | – | Alive/72 months |
| 26 | Anterior chamber invasion, iris invasion, extrascleral invasion, prelaminar optic nerve invasion | Enucleation (post-CT) | 6 | – | Alive/120 months |
| Stage II | |||||
| 27 | Anterior chamber invasion, iris invaasion, focal choroidal invasion, cut end of optic nerve invasion | Enucleation | 12 | + | AND/14 months |
| 28 | Anterior chamber invasion, massive choroidal invasion, cut end of optic nerve invasion | Enucleation | 12 | + | AND/82.5 months |
| Stage III | |||||
| 29 | – | – | – | LFU | |
| 30 | Anterior chamber invasion, massive choroidal invasion, scleral invasion, prelaminar optic nerve invasion | Enucleation | 7 | – | Orbital and LN relapse/9 months |
| 31 | Margins of exenteration specimen free of tumor | Exenteration (post-CT) | 4 | + | CNS relapse/12 months |
| 32 | – | – | LFUPT | ||
| 33 | Anterior chamber invasion, massive choroidal invasion, scleral invasion, cut end optic nerve invasion, extrascleral invasion | Exenteration | LFUPT | ||
| 34 | Anterior chamber invasion, iris, ciliary body invasion, focal choroidal invasion, cut end optic nerve invasion | Enucleation | 11 | + | LN relapse/45 months |
| 35 | None | Enucleation (post-CT) | 12 | + | AND/30.5 months |
| 36 | Anterior chamber invasion, iris, massive choroidal invasion, scleral invasion, prelaminar optic nerve invasion, extrascleral invasion | 10 | + | AND/21 months | |
| 37 | – | 3 | – | LFU | |
| 38 | Extensive involvement of choroid, iris invasion, episcleral sclera, pre- and post-laminar ONH | R enucleation | 10 | – | Alive/96 months |
| Stage IV | |||||
| 39 | – | – | – | – | LFU |
| 40 | – | – | – | – | LFU |
| 41 | – | – | 6 | – | LFU |
| 42 | – | LFU | |||
| 43 | – | – | – | LFU | |
| 44 | – | 11 | – | LFU | |
| 45 | – | – | – | LFU | |
| 46 | Anterior chamber invasion, iris invasion, cut end optic nerve invasion | Enucleation (post-CT) | 6 | + | Disease progression/7 months |
| 47 | – | – | – | – | LFU |
| 48 | None | Enucleation (post-CT) | 12 | + | Alive/18 months |
HRF, high-risk features; CT, chemotherapy; AND, alive and disease free; PR, partial response; CNS, central nervous system; LFU, lost to follow-up; LN, lymph node; LFUPT, lost to follow-up post-treatment; RT, radiotherapy.