Fig. 1.

Histology and morphometric evaluation of the murine yolk sac following LPS exposure (n = 8/group). A and B: photomicrographs of histological sections of the yolk sac from mice at GD15.5 after 4 h of treatment with vehicle (A) and LPS (B). C, D and E: photomicrographs of histological sections of the yolk sac from mice at GD18.5 after 24 h of treatment with vehicle (C), and after 4 h (D) and 24 h (E) of treatment with LPS. Arrowheads: endodermic epithelium; arrows: mesothelium; asterisks: mesodermic blood vessels. Hematoxylin-eosin.F, G and H: Volumetric proportion of the histological components of yolk sac from mice at GD15.5 after 4 h of LPS treatment (F) and from mice at GD18.5 after 4 h (G) and 24 h (H) of LPS treatment. Kruskal Wallis test, followed by Dun's post-test. Statistical significance was considered when p < 0.05.