Table 1.

Abnormal expression of subunits of human condensins and changes of structure of chromosomes in four types of cellular senescence

Types of cellular senescence	Abnormal expression of subunits of human condensins	Changes of structure of chromosomes	Number of literature
OIS	hCAPH2↑ hCAPH2ΔN↑ SMC2↓, SMC4↓	Formation of senescence-associated heterochromatic foci (SAHF), drives senescence via nuclear/genomic reorganization; strengthen and expand euchromatic A compartments and promote/maintain BA transitions upon senescence	[36, 37, 41 (Supplementary Fig. 8)]
RS	SMC2↓ SMC4↓ hCAP-D2(NCAPD2)↓ hCAP-D3(NCAPD3)↓ hCAP-G(NCAPG)↓ hCAP-G2(NCAPG2)↓ hCAP-H()(NCAPH)↑, hCAPH2((NCAPH2)↑	SAHF were not detected in RS cells, the sizes of both A and B compartments became significantly enlarged and the numbers of A and B compartments decreased; heterochromatin reorganization to restrain DNA damage and progression of MSC senescence via transcriptionally activating human condensins; telomere shortening	[37, 41, 43–45, 49 (Supplementary Figure S4)]
SIPS	Unpublished		[37, 41, 49]
TIS	Unpublished		[37, 41, 49]

“↑” is a symbol as upregulation of expression, “↓” is a symbol as downregulation of expression