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. Author manuscript; available in PMC: 2020 Dec 30.
Published in final edited form as: Annu Rev Clin Psychol. 2018 May 7;14:119–157. doi: 10.1146/annurev-clinpsy-050817-084847

Figure 1. Practicalities of PRS computation.

Figure 1.

Here, we exemplify using statistics from the most recent Psychiatric Genetics Consortium GWAS of schizophrenia (Schizophrenia Working Group, 2014) in which a discovery GWAS of 34,241 schizophrenia cases and 45,604 controls (initial discovery not including replication due to shared summary statistics). The effect allele and effect size for each SNP from the discovery GWAS is applied to each individual in a target dataset to create a unique person-specific polygenic risk score. We illustrate the approach using 4 SNPs. Summary statistics may be obtained here: https://www.med.unc.edu/pgc/results-and-downloads