Table 3.

SCZ PRS and Cognition.

Phenotypes	Phenotypes and Study Reference	N	Association and Effect size*
IQ Metrics and Neurocognitive Function	Neurocognitive Performance (Hatzimanolis et al., 2015)*	1,079	Continuous performance and spatial N-back: ~0.00275. No significant association with IQ or verbal n-back.
	Neurocognition and social cognition (Germine et al., 2016)*	4303 (8 – 21y); Replication: 695 (18 – 35y)	Verbal reasoning and emotion identification speed: 0.003 – 0.005 NS: 36 other accuracy and speed indices.
	Cognitive function and Education (Hagenaars et al., 2016)	36,035–112,067	Negative associations with verbal-numerical reasoning, reaction time, memory: B=−0.006 to-0.062; positive association with educational attainment: B=0.025.
	50 triats - personality, cognition, etc. (Krapohl et al., 2016)		No significant associations following multiple testing. But nominal positive correlations with English and negatively correlated with Autism Quotient: Attention to Detail.
	Cognitive function in older adults (Liebers et al., 2016)*	8, 616	Total Cognitive Function, Attention/Language, Verbal memory: 0.0004–0.0008
	Composite g and subfacets: memory digit, vocabulary, verbal, reaction time (SCZ-PRS x MDD) (Whalley et al., 2016)*	Sample 1: 16,764 CON; 2,587 MDD Sample 2: 27,476 CON; 6,049 MDD	Composite g: 0.0032 – 0.0062 (stronger in MDD); G Subfacets 0.0002 – 0.0109
	Cognition and learning, social and communication, emotion and mood regulation, behavior, age 4–9 (Riglin et al., 2017)*	5,100 – 6,952	Lower performance IQ and worse language intelligibility and fluency: up to 0.003
	Executive Function (Benca et al., 2017)*	386	Positive correlation with update specific latent variable: r < 0.2 (nom. Sig.). Negatively associated with IQ,: up to 0.01.
	Emotion recognition (Coleman et al., 2017)*	4,097 8 year old children	No association: r2=0.0001 – 0.0011
	Psychosis cognitive and physiological endophenotypes (Ranlund et al., 2017)*	Total: 1,437–3,089 drawn from SCZ: 1,087 SCZ 1st-degree relative: 822 CON: 2,333	SCZ>SCZrelatives>CON. Worse performance on block design: 0.002.. NS: digit span, RAVLT.
	SCZ and Cog performance (Wang et al., 2017b)*	1,130 Taiwanese SCZ	Not associated with SCZ: 0.0008. Lack of association PGC2 not used to test for association with cognitive phenotypes. Cognitive associations reported with PGC1.
Creativity	Creativity (Power et al., 2015)*	86, 292	Increased creativity: up to 0.055

Studies only include those using summary statistics from (Schizophrenia Working Group of the Psychiatric Genomics, 2014). Unless otherwise noted, effect size is represented as Nagelkerke’s Pseudo R² (multiply by 100 to obtain %R²); r = correlation, OR = Odds-ration, B = beta coefficient, AUC = Area Under the Curve. EA = European ancestry. AA = African ancestry. NS= non significant. When pearson’s r, OR, or d were reported, we estimated r².

^*indicates study with % of variance explained included in Figure 2.