Table 1.
Patient demographics per peritoneal cytology status (N = 24,800).
| Characteristics |
Negative |
Malignant |
P-value | aOR (95% CI) | P-value† |
|---|---|---|---|---|---|
| No. | n = 23,719 | n = 1081 | |||
| Age (yr) | 0.022 | <0.001* | |||
| <40 | 800 (3.4%) | 29 (2.7%) | 1.36 (0.90–2.07) | 0.146 | |
| 40–49 | 2176 (9.2%) | 88 (8.1%) | 1.48 (1.12–1.97) | 0.007 | |
| 50–59 | 7570 (31.9%) | 382 (35.3%) | 1.63 (1.33–2.00) | <0.001 | |
| 60–69 | 8512 (35.9%) | 388 (35.9%) | 1.34 (1.10–1.64) | 0.004 | |
| 70–79 | 3584 (15.1%) | 135 (12.5%) | 1 | ||
| ≥80 | 1077 (4.5%) | 59 (5.5%) | 1.39 (1.01–1.90) | 0.044 | |
| Year | 0.445 | ||||
| 2010 | 3265 (13.8%) | 130 (12.0%) | |||
| 2011 | 3231 (13.6%) | 137 (12.7%) | |||
| 2012 | 3346 (14.1%) | 144 (13.3%) | |||
| 2013 | 3248 (13.7%) | 158 (14.6%) | |||
| 2014 | 3525 (14.9%) | 175 (16.2%) | |||
| 2015 | 3631 (15.3%) | 173 (16.0%) | |||
| 2016 | 3473 (14.6%) | 164 (15.2%) | |||
| Race/ethnicity | <0.001 | <0.001* | |||
| White | 16,846 (71.0%) | 801 (74.1%) | 1 | ||
| Black | 1529 (6.4%) | 35 (3.2%) | 0.48 (0.34–0.67) | <0.001 | |
| Hispanic | 2674 (11.3%) | 111 (10.3%) | 0.80 (0.65–0.99) | 0.042 | |
| Asian | 2250 (9.5%) | 119 (11.0%) | 0.98 (0.80–1.21) | 0.841 | |
| Others | 203 (0.9%) | 2 (0.2%) | 0.20 (0.05–0.80) | 0.023 | |
| Unknown | 217 (0.9%) | 13 (1.2%) | 1.19 (0.67–2.10) | 0.554 | |
| Marital status | 0.312 | ||||
| Single | 4486 (18.9%) | 234 (21.6%) | |||
| Married | 12,847 (54.2%) | 561 (51.9%) | |||
| Divorced | 2453 (10.3%) | 105 (9.7%) | |||
| Separated | 209 (0.9%) | 7 (0.6%) | |||
| Widowed | 2504 (10.6%) | 112 (10.4%) | |||
| Unmarried/domestic | 79 (0.3%) | 5 (0.5%) | |||
| Unknown | 1141 (4.8%) | 57 (5.3%) | |||
| Insurance | 0.792 | ||||
| Yes | 22,883 (96.5%) | 1047 (96.9%) | |||
| No | 553 (2.3%) | 22 (2.0%) | |||
| Unknown | 283 (1.2%) | 12 (1.1%) | |||
| Registry area | <0.001 | <0.001* | |||
| West | 12,681 (53.5%) | 617 (57.1%) | 1 | ||
| Central | 4521 (19.1%) | 125 (11.6%) | 0.55 (0.45–0.68) | <0.001 | |
| East | 6517 (27.5%) | 339 (31.4%) | 1.08 (0.93–1.24) | 0.326 | |
| Tumour differentiation | <0.001 | <0.001* | |||
| Well | 10,488 (44.2%) | 394 (36.4%) | 1 | ||
| Moderate | 5280 (22.3%) | 275 (25.4%) | 1.24 (1.05–1.45) | 0.010 | |
| Poor | 1826 (7.7%) | 133 (12.3%) | 1.56 (1.26–1.93) | <0.001 | |
| Unknown | 6125 (25.8%) | 279 (25.8%) | 1.14 (0.97–1.33) | 0.118 | |
| T-stage | <0.001 | <0.001* | |||
| IA | 18,870 (79.6%) | 738 (68.3%) | 1 | ||
| IB | 4246 (17.9%) | 320 (29.6%) | 1.66 (1.43–1.92) | 0.001 | |
| I NOS | 603 (2.5%) | 23 (2.1%) | 1.06 (0.69–1.62) | 0.535 | |
| Pelvic lymphadenectomy | 14 (IQR 9–20) | 14 (IQR 9–20) | <0.001 | 0.002* | |
| No | 8405 (35.4%) | 264 (24.4%) | 1 | ||
| Yes | 15,218 (64.2%) | 814 (75.3%) | 1.32 (1.13–1.55) | 0.001 | |
| Unknown | 96 (0.4%) | 3 (0.3%) | 0.60 (0.12–3.03) | 0.535 | |
| Para-aortic lymphadenectomy | 5 (IQR 3–9) | 5 (IQR 9–20) | <0.001 | 0.039* | |
| No | 16,755 (70.6%) | 659 (61.0%) | 1 | ||
| Yes | 6819 (28.7%) | 416 (38.5%) | 1.20 (1.04–1.39) | 0.012 | |
| Unknown | 145 (0.6%) | 6 (0.6%) | 1.42 (0.45–4.50) | 0.552 | |
| Tumour size (cm) | <0.001 | 0.014* | |||
| ≤2.0 | 5662 (23.9%) | 201 (18.6%) | 1 | ||
| 2.1–4.0 | 7528 (31.7%) | 398 (36.8%) | 1.27 (1.06–1.52) | 0.008 | |
| 4.1–6.0 | 3825 (16.1%) | 207 (19.1%) | 1.20 (0.98–1.47) | 0.083 | |
| 6.1–8.0 | 1179 (5.0%) | 51 (4.7%) | 0.93 (0.68–1.29) | 0.678 | |
| >8.0 | 540 (2.3%) | 33 (3.1%) | 1.29 (0.88–1.91) | 0.196 | |
| Unknown | 4985 (21.0%) | 191 (17.7%) | 0.97 (0.79–1.20) | 0.798 | |
| Hysterectomy type | 0.391 | ||||
| Simple | 22,114 (93.2%) | 1004 (92.9%) | |||
| Modified/radical | 755 (3.2%) | 35 (3.2%) | |||
| Supracervical | 213 (0.9%) | 6 (0.6%) | |||
| NOS | 637 (2.7%) | 36 (3.3%) | |||
| Postoperative therapy | <0.001 | ||||
| None | 19,263 (81.2%) | 668 (61.8%) | |||
| VBT | 2887 (12.2%) | 173 (16.0%) | |||
| WPRT | 949 (4.0%) | 79 (7.3%) | |||
| VBT/chemo | 239 (1.0%) | 64 (5.9%) | |||
| Chemo | 205 (0.9%) | 64 (5.9%) | |||
| WPRT/chemo | 140 (0.6%) | 31 (2.9%) | |||
| RT NOS | 31 (0.1%) | 1 (0.1%) | |||
| RT NOS/chemo | 5 (<0.1%) | 1 (0.1%) |
Number (% per group) or median (IQR) is shown. Percentage per row is shown in Table S2. Chi-square test for univariable analysis. A binary logistic regression model for multivariable analysis. All the preoperative and operative covariates with P <0.05 in univariable analysis were entered in the final model.
†
P-value for multivariable analysis.
*
P-value for interaction. Hosmer–Lemeshow test shows P = 0.230 indicating a good-fit model.
aOR, adjusted odds ratio; CI, confidence interval; NOS, not otherwise significant; VBT, vaginal brachytherapy; WPRT, whole pelvic radiotherapy; RT, radiotherapy; chemo, chemotherapy.