Figure 7.

Effect of cutting the sciatic nerve of various mouse mutants on EdU incorporation. Only Nf2 control (uncut) nerves show noticeable EdU incorporation consistent with Nf2 mediated Schwann cell proliferation (A-D). All cut nerves showed expected increase in proliferation as revealed with EdU uptake (E-H). However, while ND1 expression alone had only minor effects on proliferation, there was a significant decrease in proliferation in Nf2 cKO+ND1 nerves compared to NF2 cKO and control animals (*p<0.01) (I). N=6 control, N=4 Postn-Cre+ND1 (ND1), N=5 Nf2 cKO, N=5 Nf2 cKO+ND1