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Selected human miRs target SARS-CoV-2 genome that product structural protein. S protein: bind to host cell receptor, consist of two subunits; S1 define virus-host range and cellular tropism, S2 modulates virus-cell membrane fusion. E protein: form hydrophilic pores on host membranes in addition to viral recognition and pathogenesis. M protein: Three transmembrane proteins bind to nucleucapsid. N protein: Produce two domains that binding to viral RNA genome.
