Table 1.

List of selected SARS-CoV-2-encoded miRs target host gene.

miR	Target gene	Up/down Regulation	Tissue	Effect	Ref.
nCoV-MD3 -3P	p53	Down	insilico	Subvert the key role of p53 in suppress of viral replication, pulmonary vascular homeostasis and upregulation of IFN I result in respiratory infection	17
nCoV-MD241–3P	BMPR2	Down	insilico	Reduce expression of innate immune response genes like IFN I and result in respiratory infection	17
MD2-5p	CHAC1	Down	insilico	It interfered with pro-apoptotic enzyme activity and apoptosis process	15
MR147–3p	RAD9A	Down	insilico	As a checkpoint, it interfered to cell arrest when DNA damaged and need to repaired	15
MR147–3p	TMPRSS2	Up	Gut	Promote infection	24
MR385–3p	TGFBR3	Up	Innate and adaptive immune cells	It boost Th1 differentiation and modulate regulatory T-cell activation and survival	46
MR359–5p	MYH9 and ITGB5	Up	All tissue except heart for MYH9 gene	Cytoskeleton proteins are critical for viral replication and life cycle and help virus for surfing, internalization, and migration within the cell	15
MR66–3p	TNF-α	Up	Spleen	TNF-α as a key cytokines provides “cytokine storm” during inflammation	15
MR147–3p	TMPRSS2	Up	Gut	As a biological membrane interfered with maintain of intestine equilibrium i.e., transporting ions, small molecules, and macromolecules and present gastrointestinal symptoms	15
MR198–3p	ADAR	Up	Liver	It suppress IFN system responses in viral infections and manifest signs of liver damage	15
MR328–5p	RXRA	Up	Lung, spleen, gut, liver	It reduced host antiviral effect following IFN-I suppression	15