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. Author manuscript; available in PMC: 2021 Jan 31.
Published in final edited form as: Science. 2020 Jul 31;369(6503):561–565. doi: 10.1126/science.aay3983

Fig. 1. Mapping ASoC variants.

Fig. 1.

(A) Schematic of iPSC differentiation strategies. (B) PCA of OCRs from iNs, fetal brains/day-30 organoids and postmortem (PTM) adult brain. (C) Cell-type-specific ASoC rs2027349 at the SZ-associated VPS45 locus. The dashed box shows the ATAC-seq read pileups flanking rs2027349 and cell-type-specific allelic ratios. (D) Pairwise π1 estimation of ASoC sharing across cell types (7). ASoC SNPs were ascertained in the leading cell type, and π1 was estimated in the matched one. (E) Chromatin accessibility in iN-Glut vs iPSC for ASoC SNP-flanking peaks. The shaded area shows comparable (< 2-fold difference) accessibility between cell types.

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