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. Author manuscript; available in PMC: 2020 Dec 30.
Published in final edited form as: Radiat Res. 2020 Dec 1;194(6):625–635. doi: 10.1667/RADE-20-00060.1

FIG. 4.

FIG. 4.

FLASH reduces apoptosis compared to CONV within neurogenic regions, 24 h postirradiation. TUNEL assay was performed to determine levels of apoptosis within the dentate gyrus (DG) and subventricular zone (SVZ). CONV-irradiated animals exhibited a significant increase when compared to FLASH and control in both the SVZ and DG. Representative images of Tdt+ cells within the SVZ (left side) and DG (right side). Scale bars = 30 μm). Panels B and C: Analysis of Tdt+ cells within the SVZ and DG at 24 h postirradiation. Data is shown as the mean ± SEM (n = 6 per group, two images analyzed per animal). *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001 (ANOVA with Bonferroni’s multiple comparisons test).