Table 4. Genomic covariate analysis of DACH1 mutated patients compared to wild-type at MCC (n = 65 patients).
| Covariates | DACH1 | ||
|---|---|---|---|
| WT N = 53 | M N = 12 | Co-Occurrence P-valuea | |
| PTEN (n = 40) | 32/40 | 8/40 | 0.94 |
| PIK3CA (n = 35) | 26/35 | 9/35 | 0.191 |
| TP53 (n = 31) | 23/31 | 8/31 | 0.255 |
| POLE Mutation (n = 28) | 17/28 | 11/28 | 5.78E-04 |
| MLH1 Mutation (n = 22) | 12/22 | 10/22 | 2.39E-04 |
| MSH2 Mutation (n = 25) | 17/25 | 8/25 | 0.046 |
| MSH6 Mutation (n = 28) | 19/28 | 9/28 | 0.264 |
| PMS2 Mutation (n = 12) | 8/12 | 4/12 | 3.67E-07 |
| Microsatellite Instability (n = 55) | 0.1342b | ||
| MSI-High (n = 7) | 4/7 | 3/7 | |
| Microsatellite Stable (n = 48) | 40/48 | 8/48 | |
| Tumor Mutation Burden | 6.02 | 24.0 | 4.29E-05c |
a P-values were calculated using the Fisher’s exact test for categorical variables and using the student t-test for continuous variables. The co-occurrence analysis using Fisher’s exact test was performed to determine whether DACH1 mutations are mutually exclusive or tend to co-occur with other gene mutations.
b MSI data was only available for 11/12 DACH1 mutated patients and 44/53 of the DACH1 wild type patients.
c Tumor mutation burden p-value was calculated using the Wilcoxon rank sum test.