Table 2. The relation between clinical and biochemical HA variables with the severity of FPHL in 362 women.
a For 307 women only, representing 84.81% of women with FPHL. Abbreviations: BMI, body mass index; BT, bioavailable testosterone; DHEA-S, dehydroepiandrosterone sulfate; FPHL, female pattern hair loss; FT, free testosterone; HOMA-IR, homeostatic model assessment-insulin resistance; mFG, modified Ferriman Gallwey; SHBG, sex hormone-binding globulins; TT, total testosterone.
| Parameters of hyperandrogenism | FPHL severity according to Sinclair’s score | p | |||
| Mild (n=287) | Moderate (n=67) | Severe (n=8) | |||
| Clinical hyperandrogenism | |||||
| Hirsutism severity according to mFG n (%) | Mild, mFG score ≤15 (n=134) | 111 (38.7) | 20 (29.9) | 3 (37.5) | <0.001 |
| Moderate, mFG score between 16 - 25 (n=130) | 93 (32.4) | 35 (52.2) | 2 (25.0) | ||
| Severe, mFG score > 25 (n=27) | 18 (6.3) | 6 (9.0) | 3 (37.5) | ||
| No hirsutism, mFG score ≤8 (n=71) | 65 (22.6) | 6 (9.0) | 0 (0) | ||
| Presentation with acne n (%) | Yes (n=57) | 39 (13.6) | 15 (22.4) | 3 (37.5) | 0.048 |
| No (n=305) | 248 (86.4) | 52 (77.6) | 5 (62.5) | ||
| Biochemical hyperandrogenism | |||||
| TT | High (n=108) | 89 (31.0) | 16 (23.9) | 3 (37.5) | 0.461 |
| Normal (n=254) | 198 (69.0 | 51 (76.1) | 5 (62.5) | ||
| Calculated FT | High (n=188) | 154 (53.7) | 28 (41.8) | 6 (75.0) | 0.09 |
| Normal (n=174) | 133 (46.3) | 39 (58.2) | 2 (25.0) | ||
| Calculated BT | High (n=284) | 227 (79.1) | 50 (74.6) | 7 (87.5) | 0.595 |
| Normal (n=78) | 60 (20.9) | 17 (25.4) | 1 (12.5) | ||
| DHEA-S b | High (n=74) | 55 (19.2) | 17 (25.4) | 2 (25) | 0.703 |
| Normal (n=233) | 184 (64.1) | 44 (65.7) | 5 (62.5) | ||
| Other associated variables | |||||
| SHBG | Low (n=61) | 47 (16.4) | 14 (20.9) | 0 (0) | 0.600 |
| Normal (n=294) | 234 (81.5) | 52 (77.6) | 8 (100) | ||
| High (n=7) | 6 (2.1) | 1 (1.5) | 0 (0) | ||
| HOMA-IR | High (n=228) | 173 (60.3) | 48 (71.6) | 7 (87.5) | 0.077 |
| Normal (n=134) | 114 (39.7) | 19 (28.4) | 1 (12.5) | ||
| BMI | High (n=283) | 223 (77.7) | 53 (79.1) | 7 (87.5) | 0.631 |
| Normal (n=79) | 64 (22.3) | 14 (20.9) | 1 (12.5) | ||
| Duration of FPHL years (mean ± SD) | 3.33 ± 2.54 | 4.11 ± 3.28 | 2.25 ± 1.83 | 0.45 | |