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. 2021 Jan 4;131(1):e136042. doi: 10.1172/JCI136042

Figure 8. Scheme of vesicular trafficking system in CD8+ Treg cells.

Figure 8

Healthy Treg cells: Low NOTCH4 signaling induces low expression of RAB5A and RAB11A and high expression of RAB7A, leading to the repression of early and recycling endosomes and expansion of late endosomes. NOX2 is secreted on the surface of exosomes and reaches surrounding cells. GCA Treg cells: High NOTCH4 signaling induces high expression of RAB5A and RAB11A and suppresses expression of RAB7A, rerouting endosomal trafficking. Early and recycling endosomes are favored and late endosomes are disfavored, keeping NOX2 in an intracellular, nonsecretory compartment.