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. 2021 Jan 4;131(1):e138699. doi: 10.1172/JCI138699

Figure 13. Expression profile of differentially expressed A1CF RNA CLIP targets in 12-month-old A1cf–/– mice.

Figure 13

Heatmap representation of 298 genes with altered expression in liver of 12-month-old chow-fed A1cf–/– mice. Expression of A1CF RNA targets, differentially expressed in 12-month-old A1cf+/Tg, in liver of 12-month-old A1cf–/– mice. Genes upregulated in aged A1cf+/Tg mice are indicated in red; genes downregulated are indicated in blue. RNA-Seq analysis showed that of the 6 genes identified from RNA-Seq and RNA CLIP in A1cf+/Tg mice, only Cdh1 was both upregulated in A1cf+/Tg mice and downregulated in A1cf–/– mice. Cdh1 RNA expression in A1cf+/Tg and A1cf–/– liver was confirmed by qPCR (n = 6–7 per genotype). Data represent mean ± SEM, *P < 0.05 (unpaired t test).