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. 2021 Jan 4;131(1):e128114. doi: 10.1172/JCI128114

Figure 10. Absence of LDLR results in aberrant myelination in vitro.

Figure 10

(A) Immunoblotting for LDLR, MBP, and CNPase expression in oligodendrocytes of 2 genotypes (n = 3 experiments). (B) Quantification of the results in A. (C) Representative light microscopic images of MBP/O4 staining of WT and Ldlr–/– oligodendrocytes (n = 4 experiments). (D) Quantification of the results in C. (E) Representative MBP and β3-tubulin staining images of the coculture system composed of WT neurons with WT or Ldlr–/– oligodendrocytes (n = 8 experiments). (F) Quantification of the results in E. Data presented as mean ± SD. *P < 0.05,**P < 0.01 vs. WT oligodendrocytes by unpaired t test. Scale bars: 20 μm