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. 2021 Jan 4;131(1):e140424. doi: 10.1172/JCI140424

Figure 3. Hypothalamic REV-ERBs regulate diurnal eating behaviors on HFD.

Figure 3

(A and B) Food consumption in HDKO mice and their control littermates on HFD. (A) Twenty-four-hour food consumption calculated from 8 days of records are presented (n = 8–10, mean ± SEM). (B) Light phase and dark phase food consumption calculated from 48 hours of records are presented (n = 6–7, mean ± SEM). Results were compared by Mann-Whitney test. (C and D) Rebound feeding at ZT1–ZT4 after 24 hours of fasting in HDKO mice and their control littermates on NCD (C) and HFD (D) (n = 3–5, mean ± SEM). Results were compared by Mann-Whitney test. Three-hour time course of rebound feeding on HFD is also displayed (n = 3, mean ± SEM). A representative experiment is shown (of 2 separate experiments with similar results). Results were compared by repeated measures 2-way ANOVA and Holm-Šidák multiple-comparison test. *P < 0.05, **P < 0.01.