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. 2021 Jan 4;131(1):e137468. doi: 10.1172/JCI137468

Figure 1. sRBC delivery impairs bacterial control at extrapulmonary sites and worsens survival after K. pneumoniae intrapulmonary infection.

Figure 1

(A) KP was instilled intratracheally into C57BL/6 mice and was followed by challenge with young RBCs (yRBCs) or senescent RBCs (sRBCs). n = 10 mice per group. **P = 0.005 by log-rank test. (B) Total BAL cell count/mL. (C) Total BAL PMN count/mL. (D) Total BAL mononuclear cell count/mL. (E) Lung bacterial burden was estimated by CFU count/mL of tissue homogenates. (F) Spleen CFU/mL. (G) Liver CFU/mL. (H) Blood CFU/mL. (B–H) each point indicates individual mice, n = 7–8 mice/group, line indicates the median. *P < 0.05, **P < 0.01, ***P < 0.001 by 2-tailed Mann-Whitney U test.