Table 2.
Meta-analysis of the efficacy of MSC in therapy of renal injury induced by toxicant.
| Indicators | Time point | Studies | Q test | Model | OR/WMD | P |
|---|---|---|---|---|---|---|
| Number | P value | selected | (95% CI) | |||
| Scr | 2 days | 3 | 0.001 | Random | -0.88 (-1.34, -0.42) | 0.0002 |
| 3 days | 4 | 0.0004 | Random | -0.09 (-0.25, 0.06) | 0.24 | |
| 4 days | 6 | 0.0002 | Random | -0.74 (-0.95, -0.54) | <0.00001 | |
| 5 days | 6 | <0.00001 | Random | -0.46 (-0.67, -0.25) | <0.0001 | |
| 6-8 days | 7 | <0.00001 | Random | -0.55 (-0.84, -0.26) | 0.0002 | |
| 10-15 days | 11 | <0.00001 | Random | -0.37 (-0.53, -0.20) | <0.0001 | |
| 28-30 days | 7 | <0.00001 | Random | -0.53 (-1.04, -0.02) | 0.04 | |
| ≥42 days | 6 | <0.00001 | Random | -0.22 (-0.39, -0.06) | 0.007 | |
| BUN | 2-3 days | 6 | <0.00001 | Random | -25.08 (-37.49, -12.67) | <0.0001 |
| 4-5 days | 8 | <0.00001 | Random | -45.71 (-59.36, -32.05) | <0.00001 | |
| 6-8 days | 5 | <0.00001 | Random | -57.55 (-99.19, -15.91) | 0.007 | |
| 13-15 days | 4 | <0.00001 | Random | -13.40 (-32.34, 5.54) | 0.17 | |
| ≥28 days | 8 | <0.00001 | Random | -23.39 (-36.39, -10.40) | 0.0004 | |
| UAE | — | 3 | 0.72 | Fixed | -22.66 (-26.41, -18.90) | <0.00001 |
| MDA | — | 4 | 0.41 | Fixed | -17.21 (-20.38, -14.04) | <0.00001 |
| GSH | — | 4 | <0.00001 | Random | 4.62 (2.74, 6.50) | <0.00001 |
| SOD | — | 3 | <0.00001 | Random | 5.42 (2.92, 7.93) | <0.0001 |
| Renal pathology | ||||||
| Inflammatory cells | — | 4 | <0.00001 | Random | -2.66 (-3.83, -1.49) | <0.00001 |
| Necrotic tubule | — | 2 | <0.00001 | Random | -2.58 (-4.75, -0.40) | 0.02 |
| Regenerative tubules | — | 2 | — | Fixed | 6.00 (3.45, 8.55) | <0.00001 |
| Renal interstitial fibrosis | — | 3 | <0.00001 | Random | -5.82 (-7.41, -4.23) | <0.00001 |
Note: Scr: serum creatinine; BUN: blood urea nitrogen; UAE: urinary albumin excretion; Ccr: creatinine clearance rate; MDA: malondialdehyde; GSH: L-glutathione; SOD: superoxide dismutase.