Fig. 5.

Linear combination of weighted biomass function with adapted boundaries for L-lysine exchange. The objective function was defined as linear combination of the host maintenance and VBOF by weighting the proportion of the respective biomass functions between 0 and 1. The sum of the two weights always sums up to 1. The upper and lower bounds of the L-lysine exchange were adapted based on the host-derived enforcement results (see Section 2.5.2). Even when the objective function is solely defined by the VBOF (% of virus BOF in objective =100%), the growth rate of the host still exceeds the growth rate of the virus