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. 2020 Dec 22;33(12):108534. doi: 10.1016/j.celrep.2020.108534

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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k-DDX60 Structure and Interactions within the 43S PIC

(A) The cryo-EM structure of the T. cruzi 43S PIC highlighting k-DDX60 (colored in dark turquoise). eIF2, 3, and 5 densities were removed for clarity.

(B) Cartoon representation of a partial atomic model of the T. cruzi 43S PIC.

(C) A close-up view of the k-DDX60 A-site insert showing its interaction with the anticodon stem loop (ASL).

(D) Schematic representation of the k-DDX60 domains. Pink boxes indicate the domains that could not be modeled because of their lower local resolution (see Figure S1B).

(E) Cartoon representation of the atomic model of the k-DDX60 and its interactions with the 43S PIC color coded in accordance with its schematic representation in (D).